- Claude Bernard -

“The joy of discovery is certainly the liveliest that the mind of man can ever feel”

Aug 2021 Non-viral gene delivery utilizing RALA modulates sFlt-1 secretion, important for preeclampsia. Nanomedicine


July 2021 Plasma Amino Acids Metabolomics' Important in Glucose Management in Type 2 Diabetes. Frontiers in Pharmacology  https://doi.org/10.3389/fphar.2021.695418

June 2021 FKBPL and SIRT-1 Are Downregulated by Diabetes in Pregnancy Impacting on Angiogenesis and Endothelial Function. Frontiers in Endocrinology 


June 2021 Stem cell-based approaches in cardiac tissue engineering: controlling the microenvironment for autologous cells. Biomedicine & Pharmacotherapy

April 2021 Considerations to Model Heart Disease in Women with Preeclampsia and Cardiovascular Disease. Cells 


April 2021 Characterisation of cardiac health in the reduced uterine perfusion pressure model and a 3D cardiac spheroid model, of preeclampsia. Biology of Sex Differences 


April 2021 3D Bioprinted cancer models: Revolutionizing personalized cancer therapy. Translational Oncology  https://doi.org/10.1016/j.tranon.2021.101015

March 2021 Extracellular Vesicles from Mesenchymal Stromal Cells for the Treatment of Inflammation-Related Conditions.International Journal of Molecular Sciences 


March 2021 Simple-to-Operate Approach for Single Cell Analysis Using a Hydrophobic Surface and Nanosized Droplets.

Analytical Chemistry


Jan 2021 GSTM1 Modulates Expression of Endothelial Adhesion Molecules in Uremic Milieu. Oxidative medicine and cellular longevity https://doi.org/10.1155/2021/6678924

Dec 2020 FKBPL is associated with metabolic parameters and is a novel determinant of cardiovascular disease. Scientific Reports

Oct 2020 FKBPL and SIRT-1, key angiogenesis proteins, are downregulated by diabetes in pregnancy. https://www.medrxiv.org/content/10.1101/2020.10.06.20208116v1 

Aug 2020 Mechanisms of Key Innate Immune Cells in Early- and Late-Onset Preeclampsia. Frontiers in Immunology.


July 2020 Role of a novel angiogenesis FKBPL-CD44 pathway in preeclampsia risk stratification and mesenchymal stem cell treatment. Journal of Clinical Endocrinology and Metabolism. https://doi.org/10.1210/clinem/dgaa403

July 2020 Cardiac Health in the Reduced Uterine Perfusion Pressure Rat Model of Preeclampsia. Journal of Paediatrics and Child Health. https://onlinelibrary.wiley.com/doi/10.1111/jpc.14868

June 2020 Top Notch Targeting Strategies in Cancer: A Detailed Overview of Recent Insights and Current Perspectives. Cells. https://www.mdpi.com/2073-4409/9/6/1503


May 2020 Can Stem Cells Beat COVID-19: Advancing Stem Cells and Extracellular Vesicles Toward Mainstream Medicine for Lung Injuries Associated With SARS-CoV-2 Infections. Front. Bioeng. Biotechnol. https://doi.org/10.3389/fbioe.2020.00554 

May 2020 Emerging therapeutic potential of mesenchymal stem cells in preeclampsia. Curr Hypertens Rep. https://link.springer.com/article/10.1007/s11906-020-1034-8

Apr 2020 Mechanisms of heart failure with preserved ejection fraction in the presence of diabetes mellitus. Translational Metabolic Disorder Research. https://doi.org/10.1016/j.tmsr.2020.04.002

Apr 2020 Diagnostics and prognostic potential of current biomarkers in heart failure with preserved ejection fraction: a systematic review and meta-analysis. https://www.medrxiv.org/content/10.1101/2020.04.18.20070482v1

March 2020 Overlapping Pathogenic Signalling Pathways and Biomarkers in Preeclampsia and Cardiovascular Disease. Pregnancy Hypertens. https://doi.org/10.1016/j.preghy.2020.03.011

March 2020 FKBPL, a novel player in cardiac ischaemia and fibrosis. Journal of Molecular and Cellular Cardiology. https://www.jmmc-online.com/article/S0022-2828(19)30233-0/abstract

Nov 2019  FKBPL-based peptide, ALM201, targets angiogenesis and cancer stem cells in ovarian cancer. Br J Cancer



Sep 2019 Service evaluation of diabetes management during pregnancy in a regional maternity hospital: potential scope for increased self-management and remote patient monitoring through mHealth solutions. BMC Health Serv Res.


Sep 2019 Association between Galectin-3 levels within central and peripheral venous blood, and adverse left ventricular remodelling after first acute myocardial infarction. Sci Rep



Aug 2019 An Integrative Biomedical Informatics Approach to Elucidate the Similarities Between Pre-Eclampsia and Hypertension. Stud Health Technol Inform


July 2019 Association of Nrf2, SOD2 and GPX1 Polymorphisms with Biomarkers of Oxidative Distress and Survival in End-Stage Renal Disease Patients. Toxins


June 2019 Markers of Oxidative Stress and Endothelial Dysfunction Predict Haemodialysis Patients Survival. Am J Nephrol.


Apr 2019 FKBPL and its peptide derivatives inhibit endocrine therapy resistant cancer stem cells and breast cancer metastasis by downregulating DLL4 and Notch4. BMC Cancer


Apr 2019 Hypercapnic acidosis induces mitochondrial dysfunction and impairs the ability of mesenchymal stem cells to promote distal lung epithelial repair. FASEB J


Dec 2018 Engaging hard-to-reach populations in research on health in pregnancy: the value of Boal's simultaneous dramaturgy. Arts Health. https://www.ncbi.nlm.nih.gov/pubmed/31038424 

Oct 2018 Downregulation of FKBPL influences metabolic and vascular function in experimental model of diabetes. Diabetologia. https://www.easd.org/virtualmeeting/home.html#!resources/downregulation-of-fkbpl-influences-metabolic-and-vascular-function-in-experimental-model-of-diabetes

June 2018 Mesenchymal stem cells influence trophoblast and endothelial cell functionality important for prevention of pre-eclampsia via a novel anti-angiogenic protein, FKBPL. Journal of Hypertension. https://journals.lww.com/jhypertension/Abstract/2018/06001/MESENCHYMAL_STEM_CELLS_INFLUENCE_TROPHOBLAST_AND.461.aspx

July 2018 FKBPL as a novel therapeutic target and prognostic biomarker in high grade serous ovarian cancer. Cancer Research. https://cancerres.aacrjournals.org/content/78/13_Supplement/LB-054.short

March 2018 4 The role of a novel anti-angiogenic protein, FKBPL, in angiogenesis associated with cardiac dysfunction. Heart. https://heart.bmj.com/content/104/Suppl_4/A2.1?utm_term=1-B&utm_content=americas&utm_campaign=alljjs&utm_medium=cpc&utm_source=trendmd

Feb 2018 Risk of pre-eclampsia in women taking metformin: a systematic review and meta-analysis. Diabetic Medicine


Sept 2017 Elucidating the role of novel angiogenesis-related proteins, FKBPL and SIR-1, in trophoblast cells exposed to diabetic stimuli: potential implications for preeclampsia. Diabetologia.


Sept 2017 FKBPL, a novel angiogenesis-related protein, is downregulated in response to myocardial stress. Irish Journal of Medical Science. https://link.springer.com/article/10.1007/s11845-017-1670-4


Oct 2017 Elucidating the Pathogenesis of Pre-eclampsia Using In Vitro Models of Spiral Uterine Artery Remodelling. Curr Hypertens Rep. https://link.springer.com/article/10.1007%2Fs11906-017-0786-2  

Oct 2015 RALA-mediated delivery of FKBPL nucleic acid therapeutics. Nanomedicine (Lond).


March 2015 The Role of Peptidyl Prolyl Isomerases in Aging and Vascular Diseases. Curr Mol Pharmacol.


Apr 2015 FKBPL is a critical antiangiogenic regulator of developmental and pathological angiogenesis. ATVB


Apr 2015 FKBPL: a marker of good prognosis in breast cancer. Oncotarget.


June 2014 Identification of RBCK1 as a novel regulator of FKBPL: implications for tumor growth and response to tamoxifen. Oncogene. https://www.nature.com/articles/onc2013306 

Jul 2013 Targeting treatment-resistant breast cancer stem cells with FKBPL and its peptide derivative, AD-01, via the CD44 pathway. Cli Cancer Res.


Feb 2013 The anti-migratory effects of FKBPL and its peptide derivative, AD-01: regulation of CD44 and the cytoskeletal pathway. PLoS ONE