Our Work

3D Bioprinted Models of Trophoblast Organoids 

3D Microfluidics Models of Vascularised Tissue

Proteomic approaches to identify novel biomarkers of early- and late-onset preeclampsia

FKBPL signalling in placental development and growth

FKBPL targeting personalised treatment for preeclampsia

Mesenchymal stem/stromal cells as a new therapeutic option for preeclampsia

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3D Bioprinted Trophoblast Organoids

This image shows the immunostaining of a growth factor receptor in a 3D bioprinted trophoblast organoid. Trophoblast cells in the placenta have a crucial role in establishing a connection between the mother and baby during pregnancy. This model can be used to investigate pregnancy and serious diseases such as preeclampsia.

Work by Mrs Claire Richards - PhD Candidate, Faculty of Science, School of Life Sciences, University of Technology Sydney, Australia

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3D Microfluidics Models of Vascularised Tissue

Vascular network formation of human umbilical vein endothelial cells (HUVECs) co-cultured with human first trimester trophoblast cells in a 3D-microfluidic device. This 3D human placenta microfluidic model has been designed to investigate the endothelial and trophoblast cells' interaction in placental development and vascular dysfunction in preeclampsia.

Work by Ms Sahar Ghorbanpour - PhD Candidate, Faculty of Science, School of Life Sciences, University of Technology Sydney, Australia

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Proteomic approaches to identify novel biomarkers of early- and late-onset preeclampsia

Proteomic analysis of the plasma samples was performed from women with early-onset preeclampsia (EOPE), late-onset preeclampsia (LOPE) and healthy pregnancies. (a) Principal component analysis (PCA) plot of proteomic data in EOPE, LOPE and healthy pregnancy groups. (b) Multigroup heatmap with hierarchical clustering dendrogram of proteomic data levels across EOPE, LOPE and healthy pregnancy groups.

Work by Mr Hao Chen - PhD Candidate, Faculty of Science & Centenary Institute, University of Technology Sydney, Australia

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FKBPL targeting personalised treatment for preeclampsia

FKBPL as a critical angiogenesis regulator has shown to play an important role in the pathogenesis and diagnosis of preeclampsia. We are exploring FKBPL targeting therapies as potential personalised treatment for both prevention and treatment of preeclampsia in combination with FKBPL and CD44 as companion diagnostics.

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